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Forme de la mise sur le site Auteur du résumé Date de mise sur le site Résumé Pratique Dr D.Mennecier 29/08/02
La génétique de la maladie coeliaque
Stratégies
de recherche de facteurs de risque génétique
L'existence d'une prédisposition génétique a été fortement soupçonnée devant la constatation d'une agrégation familiale de la maladie et par les études de concordance entre jumeaux
Approche gènes candidats
Maladie coeliaque et gènes de la région HLA
L'association des gènes HLA de classe II avec la maladie coeliaque est bien connue.
Maladie coeliaque et gènes non liés au HLA
gène cytotoxic T lymphocyte associated-4 (CTLA-4), codant un antigène de surface des lymphocytes T activés, qui régule négativement leur activation en induisant leur apoptose
Différentes études ont montré des associations de ce gène avec
Recherche systématique de liaison génétique sur l'ensemble du génome
La première étude réalisée sur 15 familles irlandaises par l'équipe de Zhong a suggéré des liaisons entre la maladie et 5 régions chromosomiques, en dehors de la région HLA
Article de base ayant permis la réalisation de ce résumé :
La génétique de la maladie coeliaque
Fabienne Clot,
Marie-Claude Babron,
Françoise Clerget-Darpoux
F. Clot, M.C. Babron, F. Clerget-Darpoux :
INSERM Génétique Epidémiologique et Structure des Populations Humaines,
Bâtiment Gregory Pincus, 80 rue du Général Leclerc, 94276 Le Kremlin Bicêtre cedex, France
Médecine thérapeutique / Pédiatrie. Vol. 4, Numéro 4, Juillet - Août 2001 : 263-7
Copyright - Editions John Libbey Eurotext
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