Diapositive PPT

Serum Concentration

0 4 24 1 2 4 6 8

1433pc-6.IL7

Hours

Median Infliximab (mg/mL)

1000

100

10

1

<0.1

1 mg/kg (n=5)

Weeks

Time Following End of Infusion

5 mg/kg (n=5)

10 mg/kg (n=5)

20 mg/kg (n=5)

In this figure, the time scale on the x-axis is broken into hours and weeks to show the dose proportionality observed with the escalating doses of infliximab. Serum infliximab concentration is shown with a logarithmic scale on the y-axis, and the assay l