Diapositive PPT

Dose Dependent Neutralization of TNFa by Infliximab

0 1 2 3 4 5 6

1751 d

Hours Post Endotoxin

Free TNFa (mg/mL)

400

200

100

80

60

40

20

0

Placebo (n=5)

0.01 mg/kg (n=5)

0.1 mg/kg (n=5)

1 mg/kg (n=5)

10 mg/kg (n=5)

This slide shows the dose-dependent neutralization of TNFa by infliximab. The median amount of free TNFa produced following endotoxin administration in the placebo control group is shown with a red line. Treatment with 0.01 or 0.1 mg/kg of infliximab, a