Treatment of HBV infection
Combination therapies
Chronological and immunological considerations
Boni C et al. JCI 1998: 102 968-7
= YMDD mutations in 16-32% per year (50% after 3 years) Leung NW et al. J Hepatol 1999
= ALT > 5N <5N > 2N < 2N
% Seroconversion 64 26 5 (p<0.001)
Chien RN et al. Hepatology 1999
= immune rebound ALT flare & decrease of HBV DNA
= lysis of infected hepatocytes
= a case report
Liaw YF et al. J Gastroenterol Hepatol 1999
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