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Biliary Tract
Increasing incidence and mortality of primary intrahepatic
cholangiocarcinoma in the United States (*Human Study*)
Tushar Patel (Abstract)
Chronic liver disease
Steatosis accelerates the progression of liver damage of
chronic hepatitis C patients and correlates with specific HCV
genotype and visceral obesity (*Human Study*)
Luigi E. Adinolfi, Michele Gambardella, Augusto Andreana, Marie-françoise
Tripodi, Riccardo Utili, Giuseppe Ruggiero (Abstract)
Partially reversible renal tubular damage in patients with
obstructive jaundice (*Human Study*)
Eleni Bairaktari, George Liamis, Orestes Tsolas, Moses Elisaf
(Abstract)
Increased density of brain histamine H1 receptors in
rats with portacaval anastomosis and in cirrhotic patients with
chronic hepatic encephalopathy
Violina Lozeva, Leena Tuomisto, David Sola, Carme Plumed, Mikko
Hippeläinen, Roger Butterworth (Abstract)
Growth Regulation and Cancer
Global changes in interleukin-6dependent gene expression
patterns in mouse livers after partial hepatectomy
Wei Li, Xianping Liang, Julie I. Leu, Kellen Kovalovich, Gennaro
Ciliberto, Rebecca Taub (Abstract)
Expression of anti-OV6 antibody and anti-N-CAM antibody along
the biliary line of normal and diseased human livers (*Human
Study*)
Marius C. Van Den Heuvel, Maarten J. H. Slooff, Lydia Visser,
Michael Muller, Koert P. De Jong, Sibrand Poppema, Annette S.
H. Gouw (Abstract)
Liver transplantation for hepatocellular carcinoma: Expansion
of the tumor size limits does not adversely impact survival (*Human
Study*)
Francis Y. Yao, Linda Ferrell, Nathan M. Bass, Jessica J. Watson,
Peter Bacchetti, Alan Venook, Nancy L. Ascher, John P. Roberts
(Abstract)
Earlier expression of the transcription factor HFH-11b diminishes
induction of p21CIP1/WAF1 levels and accelerates mouse
hepatocyte entry into S-phase following carbon tetrachloride liver
injury
Xinhe Wang, Nai-Jung Hung, Robert H. Costa (Abstract)
An early lesion in hepatic carcinogenesis: Loss of heterozygosity
in human cirrhotic livers and dysplastic nodules at the 1p36-p34
region (*Human Study*)
Min Sun, James R. Eshleman, Linda D. Ferrell, Gretta Jacobs, Eulalia
C. Sudilovsky, Ralph Tuthill, Mahmoud R. Hussein, Oscar Sudilovsky
(Abstract)
Inflammation, Cytokines, and Fibrosis
Induction of Mdr1b expression by tumor necrosis
factor- in rat liver cells is independent of p53 but requires
NF-B signaling
Jenny E. Ros, John D. Schuetz, Mariska Geuken, Konrad Streetz,
Han Moshage, Folkert Kuipers, Michael P. Manns, Peter L. M. Jansen,
Christian Trautwein, Michael Müller (Abstract)
Liver Cell Injury and Apoptosis
Caspase inhibition reduces apoptotic death of cryopreserved
porcine hepatocytes
Toshikazu Yagi, Joseph A. Hardin, Yunuen M. Valenzuela, Hideyuki
Miyoshi, Gregory J. Gores, Scott L. Nyberg (Abstract)
Etoposide prevents apoptosis in mouse liver with D-galactosamine/lipopolysaccharideinduced
fulminant hepatic failure resulting in reduction of lethality
Tetsufumi Nakama, Shuichi Hirono, Akihiro Moriuchi, Satoru Hasuike,
Kenji Nagata, Takeshi Hori, Akio Ido, Katsuhiro Hayashi, Hirohito
Tsubouchi (Abstract)
Metabolism, Transport, and Genetic Diseases
Biliary cholesterol hypersecretion in gallstone-susceptible
mice is associated with hepatic up-regulation of the high-density
lipoprotein receptor SRBI
Michael Fuchs, Boris Ivandic, Oliver Müller, Carmen Schalla,
Jürgen Scheibner, Petra Bartsch, Eduard F. Stange (Abstract)
Alterations in tight junctions differ between primary biliary
cirrhosis and primary sclerosing cholangitis (*Human Study*)
Shotaro Sakisaka, Takumi Kawaguchi, Eitaro Taniguchi, Shinichiro
Hanada, Kurumi Sasatomi, Hironori Koga, Masaru Harada, Rina Kimura,
Michio Sata, Norimasa Sawada, Michio Mori, Satoru Todo, Toshihiko
Kurohiji (Abstract)
Differential effects of microsomal enzymeinducing chemicals
on the hepatic expression of rat organic anion transporters, OATP1
and OATP2
Lesley C. Rausch-Derra, Dylan P. Hartley, Peter J. Meier, Curtis
D. Klaassen (Abstract)
Viral Hepatitis
Protective immune response to hepatitis C virus in chimpanzees
rechallenged following clearance of primary infection
Suzanne E. Bassett, Bernadette Guerra, Kathleen Brasky, Emil Miskovsky,
Michael Houghton, Gary R. Klimpel, Robert E. Lanford (Abstract)
Inhibition of hepatitis B virus DNA replication by imino sugars
without the inhibition of the DNA polymerase: Therapeutic implications
Anand Mehta, Sandra Carrouée, Bertha Conyers, Robert Jordan,
Terry Butters, Raymond A. Dwek, Timothy M. Block (Abstract)
Intrahepatic hepatitis C viral RNA status of serum polymerase
chain reactionnegative individuals with histological changes
on liver biopsy (*Human Study*)
Sharon Barrett, Niamh Kieran, Eleanor Ryan, J. Conor O'Keane,
John Crowe (Abstract)
Expression of hepatitis C virus NS5A natural mutants in a hepatocytic
cell line inhibits the antiviral effect of interferon in a PKR-independent
manner (*Human Study*)
Philippe Podevin, Abdelmajid Sabile, Rodrigo Gajardo, Nadira Delhem,
Annie Abadie, Pierre-Yves Lozach, Laura Beretta, Christian Bréchot
(Abstract)
Protracted, but not acute, hepatitis A virus infection is strongly
associated with HLA-DRB1*1301, a marker for pediatric autoimmune
hepatitis (*Human Study*)
Leonardo Fainboim, Maria Cristina Cañero Velasco, Cintia
Y. Marcos, Mirta Ciocca, Adriana Roy, Graciela Theiler, Monica
Capucchio, Silvia Nuncifora, Livio Sala, Marta Zelazko (Abstract)
Interferon alfa down-regulates CD81 in patients with chronic
hepatitis C (*Human Study*)
Bernd Kronenberger, Brigitte Rüster, Robert Elez, Stephan
Weber, Albrecht Piiper, Jung-Hun Lee, W. Kurt Roth, Stefan Zeuzem
(Abstract)
Extended lamivudine treatment in patients with chronic hepatitis
B enhances hepatitis B e antigen seroconversion rates: Results
after 3 years of therapy (*Human Study*)
Nancy W. Y. Leung, Ching-Lung Lai, Ting-Tsung Chang, Richard Guan,
Chuan-Mo Lee, Keng-Yeen Ng, Seng-Gee Lim, Pui-Chee Wu, Julie C.
Dent, Sally Edmundson, Lynn D. Condreay, Rong-Nan Chien, on behalf
of the Asia Hepatitis Lamivudine Study Group (Abstract)
Identification of immunodominant hepatitis C virus (HCV)-specific
cytotoxic T-cell epitopes by stimulation with endogenously synthesized
HCV antigens (*Human Study*)
Simona Urbani, Jacopo Uggeri, Yoshiharu Matsuura, Tatsuo Miyamura,
Amalia Penna, Carolina Boni, Carlo Ferrari (Abstract)
RAPID COMMUNICATIONS:
Germline Mutations of EXO1 Gene in Patients With
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) and Atypical
HNPCC Forms
YING WU, MARAN J. W. BERENDS, JAN G. POST, ROB G. J. MENSINK,
EDWIN VERLIND, TINEKE VAN DER SLUIS, CLAUDIA KEMPINGA, ROLF H.
SIJMONS, ATE G. J. VAN DER ZEE, HARRY HOLLEMA, JAN H. KLEIBEUKER,
CHARLES H. C. M. BUYS, and ROBERT M. W. HOFSTRA
Gastroenterology 2001 120: 1580-1587. Published online May 15
2001. [Abstract]
ALIMENTARY TRACT:
Acid, Nonacid, and Gas Reflux in Patients With Gastroesophageal
Reflux Disease During Ambulatory 24-Hour pH-Impedance Recordings
DANIEL SIFRIM, RICHARD HOLLOWAY, JIRI SILNY, ZHANG XIN, JAN TACK,
ANTOON LERUT, and JOZEF JANSSENS
Gastroenterology 2001 120: 1588-1598. Published online May 25
2001. [Abstract]
Simultaneous Intraesophageal Impedance and pH Measurement
of Acid and Nonacid Gastroesophageal Reflux: Effect of Omeprazole
MARCELO F. VELA, LUCIANA CAMACHO-LOBATO, RAMESH SRINIVASAN, RADU
TUTUIAN, PHILIP O. KATZ, and DONALD O. CASTELL
Gastroenterology 2001 120: 1599-1606. Published online May 25
2001. [Abstract]
Long-term Nonsurgical Management of Barrett's Esophagus
With High-Grade Dysplasia
THOMAS G. SCHNELL, STEPHEN J. SONTAG, GREGORIO CHEJFEC, GERARD
ARANHA, ADRIENNE METZ, SUSAN O'CONNELL, ULLA J. SEIDEL, and AMNON
SONNENBERG
Gastroenterology 2001 120: 1607-1619. Published online May 25
2001. [Abstract]
Fluorescence, Reflectance, and Light-Scattering Spectroscopy
for Evaluating Dysplasia in Patients With Barrett's Esophagus
IRENE GEORGAKOUDI, BRIAN C. JACOBSON, JACQUES VAN DAM, VADIM BACKMAN,
MICHAEL B. WALLACE, MARKUS G. MÜLLER, QINGGUO ZHANG, KAMRAN
BADIZADEGAN, DON SUN, GORDON A. THOMAS, LEV T. PERELMAN, and MICHAEL
S. FELD
Gastroenterology 2001 120: 1620-1629. Published online May 25
2001. [Abstract]
Extent of High-Grade Dysplasia in Barrett's Esophagus Correlates
With Risk of Adenocarcinoma
NAVTEJ S. BUTTAR, KENNETH K. WANG, THOMAS J. SEBO, DARREN M. RIEHLE,
KRISHNAWATIE K. KRISHNADATH, LORI S. LUTZKE, MARLYS A. ANDERSON,
TANYA M. PETTERSON, and LAWRENCE J. BURGART
Gastroenterology 2001 120: 1630-1639. Published online May 25
2001. [Abstract]
Cost-Utility of Initial Medical Management for Crohn's Disease
Perianal Fistulae
KRISTEN O. ARSENEAU, STEVEN M. COHN, FABIO COMINELLI, and ALFRED
F. CONNORS, Jr.
Gastroenterology 2001 120: 1640-1656. Published online May 25
2001. [Abstract]
Prevalence and Distinctive Biologic Features of Flat Colorectal
Adenomas in a North American Population
YUSUKE SAITOH, IRVING WAXMAN, A. BRIAN WEST, NIKOLAY K. POPNIKOLOV,
ZORAN GATALICA, JIRO WATARI, TAKESHI OBARA, YUTAKA KOHGO, and
PANKAJ J. PASRICHA
Gastroenterology 2001 120: 1657-1665. Published online May 25
2001. [Abstract]
Colonic Epithelial hPepT1 Expression Occurs in Inflammatory
Bowel Disease: Transport of Bacterial Peptides Influences Expression
of MHC Class 1 Molecules
DIDIER MERLIN, MUSTAPHA SI-TAHAR, SHANTHI V. SITARAMAN, KAREN
EASTBURN, IFOR WILLIAMS, XIA LIU, MATTHIAS A. HEDIGER, and JAMES
L. MADARA
Gastroenterology 2001 120: 1666-1679. Published online May 25
2001. [Abstract]
Aberrant Expression of G1-Phase Cell Cycle Regulators in
Flat and Exophytic Adenomas of the Human Colon
JIRINA BARTKOVA, MINNA THULLBERG, PREMYSL SLEZAK, EDGAR JARAMILLO,
CARLOS RUBIO, LARS H. THOMASSEN, and JIRI BARTEK
Gastroenterology 2001 120: 1680-1688. Published online May 25
2001. [Abstract]
LST-2, A Human Liver-Specific Organic Anion Transporter,
Determines Methotrexate Sensitivity in Gastrointestinal Cancers
TAKAAKI ABE, MICHIAKI UNNO, TOHRU ONOGAWA, TARO TOKUI, TOHRU NORIKO
KONDO, RIE NAKAGOMI, HISANOBU ADACHI, KOH FUJIWARA, MITSUNORI
OKABE, TAKEHIRO SUZUKI, KAZUO NUNOKI, EIICHI SATO, MASAYUKI KAKYO,
TOSHIYUKI NISHIO, JUNICHI SUGITA, NAOKI ASANO, ** MASAYUKI TANEMOTO,
MAKOTO SEKI, FUMIKO DATE, KATSUHIKO ONO, YOSHIAKI KONDO, KENICHI
SHIIBA, MASANORI SUZUKI, HARUO OHTANI, TOORU SHIMOSEGAWA, KAZUIE
IINUMA, HIROSHI NAGURA, SADAYOSHI ITO, and SEIKI MATSUNO
Gastroenterology 2001 120: 1689-1699. Published online May 25
2001. [Abstract]
PKC- Inhibits Anchorage-Dependent and -Independent Growth,
Enhances Differentiation, and Increases Apoptosis in CaCo-2 Cells
SONIA R. CERDA, MARC BISSONNETTE, BETH SCAGLIONE-SEWELL, MATTHEW
R. LYONS, SHARAD KHARE, REBA MUSTAFI, and THOMAS A. BRASITUS Gastroenterology
2001 120: 1700-1712. Published online May 25 2001. [Abstract]
Targeting Cyclooxygenase 2 and HER-2/neu Pathways
Inhibits Colorectal Carcinoma Growth
MOSS MANN, HONGMIAO SHENG, JINYI SHAO, CHRISTOPHER S. WILLIAMS,
PAUL I. PISACANE, MARK X. SLIWKOWSKI, and RAYMOND N. DuBOIS
Gastroenterology 2001 120: 1713-1719. Published online May 25
2001. [Abstract]
The Keratin 19 Promoter Is Potent for Cell-Specific Targeting
of Genes in Transgenic Mice
FELIX H. BREMBECK, JENNIFER MOFFETT, TIMOTHY C. WANG, and ANIL
K. RUSTGI
Gastroenterology 2001 120: 1720-1728. Published online May 25
2001. [Abstract]
Role of Immunologic Factors and Cyclooxygenase 2 in Persistent
Postinfective Enteric Muscle Dysfunction in Mice
GIOVANNI BARBARA, ROBERTO DE GIORGIO, YIKANG DENG, BRUCE VALLANCE,
PATRICIA BLENNERHASSETT, and STEPHEN M. COLLINS
Gastroenterology 2001 120: 1729-1736. Published online May 25
2001. [Abstract]
Role of Peripheral N-Methyl-D-Aspartate
(NMDA) Receptors in Visceral Nociception in Rats
JAMES A. McROBERTS, SANTOSH V. COUTINHO, JUAN CARLOS G. MARVIZÓN,
EILEEN F. GRADY, MICHELE TOGNETTO, JYOTI N. SENGUPTA, HELENA S.
ENNES, VICTOR V. CHABAN, SILVIA AMADESI, CHRISTOPHE CREMINON,
TOM LANTHORN, PIERANGELO GEPPETTI, NIGEL W. BUNNETT, and EMERAN
A. MAYER
Gastroenterology 2001 120: 1737-1748. Published online May 25
2001. [Abstract]
Site of Action of GABAB Receptor for Vagal Motor
Control of the Lower Esophageal Sphincter in Ferrets and Rats
C. M. McDERMOTT, T. P. ABRAHAMS, E. PARTOSOEDARSO, N. HYLAND,
J. EKSTRAND, M. MONROE, and P. J. HORNBY
Gastroenterology 2001 120: 1749-1762. Published online May 25
2001. [Abstract]
LIVER, PANCREAS, AND BILIARY TRACT:
Genetic Alterations Associated With Hepatocellular Carcinomas
Define Distinct Pathways of Hepatocarcinogenesis
PIERRE LAURENT-PUIG, PATRICIA LEGOIX, OLIVIER BLUTEAU, JACQUES
BELGHITI, DOMINIQUE FRANCO, FREDERIC BINOT, GENEVIÈVE MONGES,
GILLES THOMAS, PAULETTE BIOULAC-SAGE, and JESSICA ZUCMAN-ROSSI
Gastroenterology 2001 120: 1763-1773. Published online May 25
2001. [Abstract]
Cryptosporidium parvum Activates Nuclear Factor
B in Biliary Epithelia Preventing Epithelial Cell Apoptosis
XIAN-MING CHEN, SUSAN A. LEVINE, PATRICK L. SPLINTER, PAMELA S.
TIETZ, AMANDA L. GANONG, CHRISTIAN JOBIN, GREGORY J. GORES, CARLOS
V. PAYA, and NICHOLAS F. LaRUSSO
Gastroenterology 2001 120: 1774-1783. Published online May 25
2001. [Abstract]
Prevention of Rat Hepatic Fibrosis by the Protease Inhibitor,
Camostat Mesilate, via Reduced Generation of Active TGF-
MASATAKA OKUNO, KUNIHARU AKITA, HISATAKA MORIWAKI, NORIFUMI KAWADA,
KAZUO IKEDA, KENJI KANEDA, YASUHIRO SUZUKI, and SOICHI KOJIMA
Gastroenterology 2001 120: 1784-1800. Published online May 25
2001. [Abstract]
Expression of Sterol 12-Hydroxylase Alters Bile Acid Pool
Composition in Primary Rat Hepatocytes and In Vivo
WILLIAM M. PANDAK, PATRICIA BOHDAN, CLIFTON FRANKLUND, DARRELL
H. MALLONEE, GÖSTA EGGERTSEN, INGEMAR BJÖRKHEM, GREGORIO
GIL, Z. RENO VLAHCEVIC, and PHILLIP B. HYLEMON
Gastroenterology 2001 120: 1801-1809. Published online May 25
2001. [Abstract]
The Bile Acid-Activated Phosphatidylinositol 3-Kinase Pathway
Inhibits Fas Apoptosis Upstream of Bid in Rodent Hepatocytes
YASUHIRO TAKIKAWA, HIDEYUKI MIYOSHI, CHRISTIAN RUST, PATRICIA
ROBERTS, RICHARD SIEGEL, PIJUS K. MANDAL, RANDAL E. MILLIKAN,
and GREGORY J. GORES
Gastroenterology 2001 120: 1810-1817. Published online May 25
2001. [Abstract]
Serine Protease Inhibitor Causes F-Actin Redistribution
and Inhibition of Calcium-Mediated Secretion in Pancreatic Acini
VIJAY P. SINGH, ASHOK K. SALUJA, LAKSHMI BHAGAT, ANTTI J. HIETARANTA,
ALBERT SONG, ANDREAS MYKONIATIS, GIJS J. D. VAN ACKER, and MICHAEL
L. STEER
Gastroenterology 2001 120: 1818-1827. Published online May 25
2001. [Abstract]
Portal hypertension
Joseph Osterwalder, J E J Krige, and I J Beckingham
BMJ 2001; 322: 1492. [Full
text]
Why should women have lower reference limits for haemoglobin
and ferritin concentrations than men?
D Hugh Rushton, Robin Dover, Anthony W Sainsbury, Michael J Norris,
Jeremy J H Gilkes, and Ian D Ramsay
BMJ 2001; 322: 1355-1357. [Full
text]
A gene for Crohn's [Full Text]
Association between insertion mutation in NOD2 gene
and Crohn's disease in German and British populations [Abstract]
Jochen Hampe, Andrew Cuthbert, Peter J P Croucher, Muddassar M
Mirza, Silvia Mascheretti, Sheila Fisher, Henning Frenzel, Kathy
King, Anja Hasselmeyer, Andrew J S MacPherson, Stephen Bridger,
Sander van Deventer, Alastair Forbes, Susanna Nikolaus, John E
Lennard-Jones, Ulrich R Foelsch, Michael Krawczak, Cathryn Lewis,
Stefan Schreiber, Christopher G Mathew
Crohn's disease: genetic susceptibility, bacteria, and innate
immunity
[Abstract]
*David A van Heel, Dermot P B McGovern, Derek P Jewell
Crohn's disease: genetic susceptibility, bacteria, and innate
immunity [Abstract]
*David A van Heel, Dermot P B McGovern, Derek P Jewell
Helicobacter pylori and symptomatic relapse of gastro-oesophageal
reflux disease: a randomised controlled trial [Abstract]
W Schwizer, M Thumshirn, J Dent, I Guldenschuh, D Menne, G Cathomas,
M Fried
Effect of nifedipine in metastatic colon cancer with DNA
mismatch repair gene defect [Abstract]
Jia-Lin Yang, Michael L Friedlander
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