Nouveaux IPP - Cinétique de l’effet antisécrétoire

Intragastric

Acidity

(mmol/L)

Day 1: Median Hourly Intragastric Acidity in Healthy Subjects

Williams MP, et al. Aliment Pharmacol Ther. 1998;12:1079-1089.

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Rabeprazole

Omeprazole

Placebo

0

N = 23

The effects of rabeprazole 20 mg once daily and omeprazole 20 mg once daily on intragastric acidity were compared in 23 H pylori-negative male volunteers in a randomized, double-blind, placebo-controlled, crossover study. (1)

Subjects received rabeprazole, omeprazole, or placebo once daily before breakfast. 24-hour intragastric acidity was measured on days 1 and 8 of dosing. Plasma gastrin concentrations were measured on day 8. (1)

24-hour median intragastric profiles on day 1 of dosing with rabeprazole 20 mg, omeprazole 20 mg, or placebo once daily in 23 healthy subjects are shown. (1)

Rabeprazole and omeprazole both significantly decreased intragastric acidity compared with placebo at all time periods on day 1 (B = breakfast; C = coffee; L = lunch; T = tea; S = supper; N = nighttime snack). (1)

Rabeprazole produced a significantly greater decrease in integrated acidity compared with omeprazole for the whole 24-hour period and for 3 of 4 meal-related time periods (afternoon, evening, and night). (1)

24-hour intragastric acidity was reduced by 66% with rabeprazole and by 35% with omeprazole as compared with placebo. (1)

Rabeprazole provides consistent control of intragastric pH over the dosing period – a feature likely to benefit patients with GERD or peptic ulcer disease. (2) Esophageal healing and symptoms of GERD are both related to gastric pH, which correlates with e

 
Williams MP, Sercombe J, Hamilton JI, Pounder RE. A placebo-controlled trial to assess the effects of 8 days of dosing with rabeprazole versus omeprazole on 24-h intragastric acidity and plasma gastrin concentrations in young healthy male adults. Aliment

Bell NJV, Burget D, Howden CW, Wilkinson J, Hunt RH. Appropriate acid suppression for the management of gastro-oesophageal reflux disease. Digestion. 1992;51(Suppl):59-67.
Hunt RH. The relationship between the control of pH and healing and symptom relief in gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 1995;9(Suppl 1):3-7.
Burget DW, Chiverton SG, Hunt RH. Is there an optimal degree of acid suppression for healing of duodenal ulcers? A model of the relationship between ulcer healing and acid suppression. Gastroenterology. 1990;99:345-351.