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In a multiple cross-over, double-blind, randomized study, 24-hour intragastric pH monitoring was performed on 17 H pylori-negative subjects on the day of a single administration of rabeprazole 20 mg (RAB), lansoprazole 30 mg (LAN), pantoprazole 40 mg (PAN
Rabeprazole was the most potent acid-inhibitor of all tested PPIs during the first 24 hours of dosing. (1)
It has been postulated that the pKa of proton pump inhibitors (PPIs) determines the degree of acid inhibition during the first 24 hours, the results from this study support this. (1)
Pantoflickova D, Dorta G, Jornod P, Ravic M, Blum AL. Identification of the characteristics influencing the degree of antisecretory activity of PPIs. Gastroenterology. 2000;118:A1290. Abstract.
