Diapositive PPT

Vaccins recombinants contre le VHC

Nouvelles approches*

• Virus-like particles vaccines 1

(core + envelope: Ab & T cell response in mice)

• Synthetic peptide vaccines (major antigenic epitopes for T cell response)2

• Live recombinant viral vaccines (attenuated recombinant adenovirus

containing core & E1: CTL induction)3

• Naked DNA vaccines (plasmid with cDNA HCV sequences) 4

• T cell directed vaccination

*small animals only

1 Baumert et al. J Virol 1998; 2 Hiranuma et al. J Gen Virol 1999;

3 Prezzi et al. J Immunol 1996; 4 Major ME et al. J Virol 1995